Institutional creator:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular Diseases

Contributor:

Walczak, Ewa ; Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular Diseases

Place of publishing:

Warsaw

Description:

Electron microscopy analysis of the heart biopsy

Abstract:

Significant changes in sarcomere pattern were observed. The ultrastructural evaluation revealed also changes in the course of myofibrils and their disorganization, often a total loss of myofibrils was noticed. Quite numerous lipid droplets were visible. The cardiomyocyte nuclei were characterized by abnormal shape, the nuclear envelope was corrugated, forming numerous invaginations, and broken in some parts. Some nucleicontained cellular organelles inside them. Focally, especially in the vicinity of cardiomyocyte nuclei deposits of lipofuscin were seen. A large accumulation of mitochondria was observed in sarcoplasm. Some of them showed ultrastructuralchanges - abnormal arrangement of mitochondrial cristae was visible.

Detailed Resource Type:

Files ; Photography

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:155613

Language:

pol ; eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open