Subtitle:

Computational modeling of the bacterial 70S ribosome and its subunits

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Type of object:

Journal/Article

Abstract:

The computational modeling studies performed on the entire 70S bacterial ribosome and its subunits are reviewed. Computational approaches became possible with the availability of three-dimensional atomic resolution structures of the ribosomal subunits. However, due to enormous size of the system theoretical efforts to study the ribosome are few and still pose a great challenge. For example, to extend the simulation time scales to biologically relevant ones, often reduced models requiring tedious parameterization procedures need to be applied. So far modeling of the ribosome involved its electrostatic properties, internal dynamics, binding of antibiotics, polypeptide folding in the ribosome tunnel, and assembly paths of proteins in the small ribosomal subunit.

Relation:

Biotechnologia, vol.84, 1 (2009)-.

Volume:

84

Issue:

1

Start page:

36

End page:

47

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:72727 ; IChB B-79

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

eng

Language of abstract:

eng

Temporal coverage:

2009

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open