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Czarnocki, D. ; Mossakowski, Mirosław ; Rap, Zbigniew ; Weinrauder, Halina
Verlag der Wiener Medizinischen Akademie
Considering the resemblance of immunological mechanismus between graft-reject-reaction and Experimental Allergic Encephalitie /E.A.E„/ our Ezperiment aimed at inducing a more durable tolerance in E.A.E. In our investigation, the rabbits received 6-Mercaptopurin intravenously, concurrently with the classical immunisation with brain suspension and Freund full adjuvant and for 18 days after. We hoped in this way to eliminate more effectively the specifio immunological clones. After stopping this drug the new sensibilisation of treated rabbits gave a much weaker response both from clinical and histological point of fiew than in control animals. The problems concerning the wider aignificance and the mechanism of the acquired tolerance needs futher conside-ration.
Licencja Creative Commons Uznanie autorstwa 4.0
Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -
Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk
Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Feb 7, 2022
Mar 25, 2019
60
https://rcin.org.pl./publication/90818
Edition name | Date |
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Brokman, H, 1971, Krzeugung Immunologischen Toleranz in Experimenteller Allergischeer Encephalitis /EAE/ | Feb 7, 2022 |