Subtitle:

Perspectives of Cell Theraphy in Parkinson's Disease

Publisher:

Medical Communication

Place of publishing:

Warszawa

Description:

191-198 s.;

Type of object:

Journal/Article

Abstract:

Both experimental studies and preliminary results of clinical trials performer during the last few years showed that supplementation of striatum by cells producing dopaminę may be effective in the treatment of Parkinson's disease. The use of neural progenitor cells cultured in vitro and directed dopaminergically by exposition to specific instructive factors or by genetic manipulation, results mainly from practical premises. This may allow to overcome the problem of limited availability of human tissue required for transplanta¬tion, to enhance epidemiologic and genetic control of biologic material and to standardize the whole procedure.The perspective of using mature, tissue-specific stem cells from such sources as bone marrow or placental blood (also from skin, olfactory epithelium, etc.) is becoming very real, thus supplying autologous grafts and overcoming difficult ethical and legal problems associated with the use of embryonal stem cells. The use of own host cells for transplantation (or their correct selection from a wide range of available cultured cel lines) would provide optimal conditions for good transplant “take" , it's full integration with host tissues and restoration of normal neural connections in the damaged striatum. This thesis is supported by recently published results of experimental studies on animal models of Parkinson’s disease, indicating the possibility of functional reconstruction of damaged corticobasal circuits after intracerebral transplantation of stem cells. Highlighted are significant problems, which must be solved, before this method will be intoduced into clinical practice.

References:

bibliografia s. 196-198

Relation:

Choroba Parkinsona. Postępy w monitorowanym klinimetrycznie rozpoznawaniu i leczeniu/ pod red. Waldemara Pokrysia. Warszawa, 2003

Detailed Resource Type:

Article

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:69586

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open