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Kuczeriszka, Marta ; Dobrowolski, Leszek ; Walkowska, Agnieszka ; Sadowski, Janusz ; Kompanowska-Jezierska, Elżbieta
Adenosine (ADO) causes vasodilation in most tissues. In the kidney it can induce vasoconstriction or vasodilation, depending on the prevailing stimulation of A1 or A2 receptors (A1R, A2R). ADO-induced alterations of renal excretion may be secondary to haemodynamic changes, or reflect a direct influence on tubular transport. This whole-kidney study explored renal excretory responses to ADO receptor stimulation as related to renal haemodynamics sodium intake and cytochrome P450 (CYP-450) activity. Methods: The effects of ADO or an A2aR agonist (DPMA) on urine flow (V), sodium excretion (UNaV) and total solute excretion were examined in anaesthetized Wistar rats on a low-sodium or high-sodium (HS) diet. Total renal blood flow (RBF; renal artery probe), and outer- and inner-medullary blood flows (OM-BF, IM-BF; laser-Doppler fluxes) were also determined. Results: Consistent opposed effects of ADO and DPMA were only observed with the HS diet. ADO increased V (150%) and UNaV (100%); there were also significant increases in RBF, OM-BF and IM-BF. These changes were prevented by 1-aminobenzotriazol, a CYP-450 inhibitor. In HS rats, DPMA significantly decreased arterial blood pressure and renal excretion. Conclusions: Post-ADO diuresis/natriuresis was in part secondary to renal hyperperfusion; the response was probably mediated by CYP-450-dependent active agents. Selective A2aR stimulation induced systemic vasodilation, major hypotension, and a secondary decrease in renal excretion
Prawa zastrzeżone - dostęp ograniczony
Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk
Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Program Operacyjny Innowacyjna Gospodarka, lata 2010-2014, Priorytet 2. Infrastruktura strefy B + R
24 mar 2022
22 gru 2015
90
https://rcin.org.pl./publication/77962
Nazwa wydania | Data |
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Kuczeriszka, M.,2013, Adenosine Effects on Renal Function in the Rat: Role of Sodium Intake and Cytochrome P450 | 24 mar 2022 |
Kompanowska-Jezierska, Elżbieta Kuczeriszka, Marta
Walkowska, Agnieszka Kuczeriszka, Marta Sadowski, Janusz Olszyński, Krzysztof Hubert Dobrowolski, Leszek Cervenka Ludek Hammock, BD Kompanowska-Jezierska, Elżbieta
Kompanowska-Jezierska, Elżbieta
Kompanowska-Jezierska, Elżbieta
Walkowska, Agnieszka Badzyńska, Bożena Kompanowska-Jezierska, Elżbieta Johns, EJ Sadowski, Janusz
Certikova-Chabova, Vera Vernerova, Zdenka Kujal, Peter Huskova, Zdenka Skaroupkova, Petra Tesal, Vladimir Kramer, Hubert J. Kompanowska-Jezierska, Elżbieta Walkowska, Agnieszka Sadowski, Janusz Cervenka, Ludek Vaneckova, Ivana
Walkowska, Agnieszka