Institutional creator:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Contributor:

Filipkowski, Robert K. (Promotor) ; Olszyński, Krzysztof H. (Promotor pomocniczy)

Publisher:

Instyytut Medycyny Doświadczalanej i Klinicznej im. M. Mossakowskiego PAN

Place of publishing:

Warszawa

Degree name:

doktor

Level of degree:

2

Degree discipline :

medical sciences

Degree grantor:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Type of object:

Praca dyplomowa

Abstract:

Rats communicate using ultrasonic vocalizations (USV). Based on the frequency range they occupy, two main types of rat ultrasounds have been distinguished: 50-kHz USV and 22-kHz USV. It has also been shown that appetitive stimuli induce 50-kHz USV, while aversive stimuli, such as pain, elicit 22-kHz USV. In our laboratory, it was demonstrated that exposure of rats to both types of USV (playback) triggers distinct behavioral responses. In addition to this procedure, the doctoral dissertation utilized fear conditioning (FC), which is based on associating electric shocks with neutral conditioned stimuli. Recently, it has been shown that the spontaneously hypertensive rat (SHR) strain exhibits behaviors similar to symptoms and deficits observed in schizophrenia, a disorder in which multiple speech-related impairments occur. This study examined the behavior of Wistar rats and SHR subjected to the FC procedure using 1, 6, or 10 painful stimuli. They were then exposed to 50- and 22-kHz USV playback in a cage similar to their home cage. It was hypothesized that prior exposure to painful stimuli would result in different behavioral responses in the rats and that SHR would differ from Wistar rats in their USV responses. Wistar rats that received 6 or 10 painful stimuli showed greater changes in locomotor activity and emitted more USV in response to USV playback than control groups. In contrast, SHR emitted significantly fewer USV than Wistar rats, and no FC effect on playback response was observed in these animals. Finally, the effect of the antipsychotic drug haloperidol on USV emission in SHR was examined. Haloperidol administration increased the number of USV emitted in response to 50-kHz USV playback. These findings indicate the potential use of USV in studying disorders associated with social communication deficits.

Detailed Resource Type:

PhD Dissertations

Format:

pdf

Resource Identifier:

oai:rcin.org.pl:243885

Source:

IMDIK PAN, sygn. ZS 440 ; click here to follow the link

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Access:

Open