Description:

Praca doktorska wykonana w Zespole Transkryptomiki Funkcjonalnej Promotor: dr hab. Kamilla Bąkowska-Żywicka, prof. ICHB PAN

Location:

Poznań

Abstract:

Development of deep sequencing and high-throughput techniques has ledto the discovery of a wide range of non-coding RNA molecules (ncRNAs). These moleculesplay key roles during regulation of gene expression and they shape cellular life. In recentyears it has been shown that under certain conditions non-coding RNAs may becomeprecursors of shorter RNAs. This relatively new topic is currently the object of intenseresearch. The existence of many unknown mechanisms that regulate important functionsof cells, such as stress response, metabolism or cell cycle has recently been shown.Lately, the existence of a new protein biosynthesis regulation pathway was discovered.It has been shown that translation may be regulated by direct association of short RNAswith ribosomes in baker′s yeast Saccharomyces cerevisiae. Short RNAs which associate withthe ribosome are named ribosome-associated noncoding RNAs (rancRNAs).Among rancRNAs, many new classes of short RNAs have been detected. These RNAs ariseduring stress conditions by processing of a well-known non-coding RNAs such as snoRNA,rRNA, mRNA or tRNA

Start page:

1

End page:

121

Detailed Resource Type:

PhD Dissertations

Format:

application/pdf

Resource Identifier:

oai:rcin.org.pl:204538

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

-

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open