Subtitle:

The use of X-ray crystallography in the designing and optimisation of the bioproducts

Publisher:

Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS

Abstract:

The role of protein and organic crystallography was discussed. X-ray analysis is an important tool inthe investigations of macromolecular structures. It can be used in evaluations of the structures (with thehighest accuracy at the moment) and mechanisms of enzymes, enzymes-inhibitors (substrates analogs)complexes, hormones, antibodies - practically all kinds of macromolecules. X-ray analysis is particularlyuseful in co-operation with protein engineering. Site directed mutagenesis can supply mutants, helping instructure - function, molecular recognition investigations, and optimizing the enzyme function. New enzymes and other proteins, with new, stricktiy required properties can be quickly obtained. X-ray analysis canalso be helpful in biotransformation research, drugs, pesticides, herbicides synthesis, and in the loweringthe costs of production. The results of protein and organic crystallography are stored in Data Banks, whichcan be used (in to the predict and to model of) new molecules.

Relation:

Biotechnologia, vol.11, 1 (1991)-.

Volume:

11

Issue:

1

Start page:

71

End page:

81

Detailed Resource Type:

Article

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:181768 ; IChB B-08

Source:

Library of Institute of Bioorganic Chemistry PAS

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Creative Commons Attribution BY-SA 4.0 license

Terms of use:

Copyright-protected material. [CC BY-SA 4.0] May be used within the scope specified in Creative Commons Attribution BY-SA 4.0 license, full text available at:

Digitizing institution:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Original in:

Institute of Bioorganic Chemistry of the Polish Academy of Science

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open