RCIN and OZwRCIN projects

Object

Title: Antysensowe oligonukleotydy jako narzędzie badania ekspresji genów w mózgu

Creator:

Szklarczyk, Arkadiusz ; Kaczmarek, Leszek

Date issued/created:

1995

Resource type:

Tekst

Subtitle:

Antisense oligonucleotides as a tool to study gene expression in the brain

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Abstract:

Antisense oligonucleotides (asODN) have recently been used to block specific gene expressionin the rodent brain. Their targets include subunits of receptors for neurotransmitters, neuropeptides and transcription factors, i.e. those proteins, whose other blockers are not known.Successful applications of the asODN require good understanding of their pharmacokinetics,mechanisms of action and side effects in the brain. Unfortunately, very little is known in thisregard. Both intraventricular and intrastructure route of administration of phosphorodiester (O- ODN) and phosphorothioate (S - ODN) ODN to the brain were effectively employed. However,doses used, even in the case of the same analog, differ up to two orders of magnitude. Sincetranslation arrest is believed to be an effective mechanism of ODN activity in the brain, mostof the authors target the ODN to the mRNA region including the translation codon, but thereare almost no studies of the target mRNA levels. The paper reviews the recent development inthis field, offering critical evaluation of the data.

Relation:

Biotechnologia, vol.28, 1 (1995)-.

Volume:

28

Issue:

1

Start page:

65

End page:

73

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:148049 ; IChB B-24

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

Otwarty

Object collections:

Last modified:

Nov 22, 2020

In our library since:

Nov 22, 2020

Number of object content downloads / hits:

96

All available object's versions:

https://rcin.org.pl./publication/183589

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