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RCIN and OZwRCIN projects

Object

Title: Struktura i funkcja cyklofillin

Creator:

Nuc, Katarzyna ; Słomski, Ryszard

Date issued/created:

2002

Resource type:

Tekst

Subtitle:

Structure and Function of Cyclophilins

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Abstract:

Cyclophilins (CyPs) constitute a large class of highly conserved, ubiquitousPPlases (EC 5.2.1.8) that together with FK560 binding proteins (FKBP) and parvulinsbelong to a superfamily of immunophilins. These three classes of proteins areeasily distinguishable by their selective interactions with immunosuppressivedrugs. Cyclophilins are targets for cyclosporin A (CsA), parvulins bind juglone(5-hydroxy-l.4-naphthoquinone) and FKBP, they are inhibited either by FK560drug or by rapamycin. Despite the lack of structural similarity, all these proteinshave been shown to act as peptidylprolyl cis-trans isomerases. In all cases, binding of the drug inhibits their PPIase activity. Distinct isoforms of cyclophilinshave been localized in the cytoplasm, nucleus, mitochondria, chloroplasts andendoplasmic reticulum.

Relation:

Biotechnologia, vol.58, 3 (2002)-.

Volume:

58

Issue:

3

Start page:

135

End page:

152

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:137917 ; IChB B-54

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

pol

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

Otwarty

Object collections:

Last modified:

Oct 2, 2020

In our library since:

Sep 4, 2020

Number of object content downloads / hits:

220

All available object's versions:

https://rcin.org.pl./publication/173026

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Struktura i funkcja cyklofillin Oct 2, 2020
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