Subtitle:

From neoplastic neural development to gene therapy of brain tumors -IGF-I antisense and triple helix approaches

Publisher:

Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN

Abstract:

IGF-I, insulin - like growth factor I, seems to play a major role in the normal and tumoral development of the nervous system. Glioblastoma is the mostfrequent brain tumor in man and is usually fatal. Both human and rat gliomacells express high amounts of lGF-1. When rat glioma cells are transfected withvectors expressing either IGF-I antisense RNA or inducing IGF RNA - DNA triplehelix, the synthesis of IGF-1 was stopped on translation or transcription levels,respectively. Down-regulation in the expression of IGF-I coincides with the reappearance of B-7 and MHC class 1 antigens at the surface of transfected cells.When injected subcutaneously, the transfected cancer cells initiate an immunereaction involving CD8-F lymphocytes, followed by tumor regression. The«anti-gene» strategy for clinical therapy of glioblastoma, and other tumors expressing IGF-I such hepatomas were introduced in University Hospitals of Cleveland (USA), Shanghai (China), Krakow and Bydgoszcz (Poland).

Relation:

Biotechnologia, vol.61, 2 (2003)-.

Volume:

61

Issue:

2

Start page:

182

End page:

191

Detailed Resource Type:

Artykuł

Format:

application/pdf

Resource Identifier:

0860-7796 ; oai:rcin.org.pl:135649 ; IChB B-57

Source:

Biblioteka Instytutu Chemii Bioorganicznej PAN

Language:

eng

Language of abstract:

eng

Temporal coverage:

1988-2010

Rights:

Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0

Terms of use:

-

Digitizing institution:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Original in:

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Projects co-financed by:

Program Operacyjny Polska Cyfrowa, lata 2014-2020, Działanie 2.3 : Cyfrowa dostępność i użyteczność sektora publicznego; środki z Europejskiego Funduszu Rozwoju Regionalnego oraz współfinansowania krajowego z budżetu państwa

Access:

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