Wydawca:

PWN

Miejsce wydania:

Warszawa

Typ obiektu:

Journal/Article

Abstrakt:

The degradation process of mitochondrial membrane phospholipids from guinea pig brain was studied in conditions of ischemia and barbiturate anesthesia. Ischemia resulted in the decrease of phosphatidylethanolamine (PE) level and in the increase of the content of free fatty acids (FFA). Calcium ions were activating PE hydrolysis and FFA release and may be the factor stimulating the activity of mitochondrial phospholipase in conditions of oxygen defficiency. The in vilro studies demonstrate that procain and the ATP+MgJ + system strongly inhibit the activity of mitochondrial phospholipase, while nembutal has no effect. Ncmbutal anesthesia decreases the hydrolytic changes of phospholipids, produced by ischemia. It is suggested that besides the geneial metabolic and physioiogical state of the celi, produced by anesthesia acetylcholine, which level in the braip is inereased twi<_e during barbiturate anesthesia, may be one of the factors of anesthesia responsible for the protection of brain mitochondriu against ischemia. In vitro, acetylcholine inhibits the activity of the mitochondrial phospholipase.

Czasopismo/Seria/cykl:

Bulletin de l'Academie Polonaise des Sciences. Serie des Sciences Biologiques

Tom:

25

Zeszyt:

2

Strona pocz.:

125

Strona końc.:

131

Szczegółowy typ zasobu:

Article

Format:

application/pdf

Identyfikator zasobu:

oai:rcin.org.pl:79298

Język:

eng

Język streszczenia:

eng

Prawa:

Creative Commons Attribution BY 4.0 license

Zasady wykorzystania:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Właściciel praw autorskich:

Strosznajder Joanna

Digitalizacja:

Mossakowski Medical Research Institute PAS

Lokalizacja oryginału:

Library of the Mossakowski Medical Research Institute PAS

Dofinansowane ze środków:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Dostęp:

Open