Gajkowska, Barbara ; Gadamski, Roman (1933–2015) ; Mossakowski, Mirosław Jan (1929–2001)
Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk
Electron microscope analysis of the CA, Ammon’s horn sector was performed in Mongolian gerbils three days after an incident of short-term ischemia of the forebrain. CAt pyramidal neurons showed advanced disintegration. Some GABA-er- gic interneurons revealed ultrastructural alteration of variable degree. The latter finding contradicts the generally helt view on the relative resistance of CAt sector interneurons to the ischemic injury. Synapses localized in all cortical layers of the CAj sector exhibited ultrastructural abnormalities involving both pre-and postsynap- tic parts. They consisted in marked swelling and accumulation of unbound electron dense material, considered as calcium deposits. Presynaptic parts revealed additionally reduced number of synaptic vesicles and their abnormal distribution. Contrary to the early postischemic period, the most severe synaptic alterations appeared in stratum pyramidale, radiatum and oriens, involving both small dendritic branchings and their spines as well as large shafts of both basal and apical pyramidal dendrites. Synaptic alterations especially features of the postsynaptic damage correspond to those indicating excitotoxic neuronal lesions. Presynaptic alterations may indicate both cessation of neurotransmission function as well as direct ischemic damage. The presence of calcium deposition seems to favour the former possibility.
Creative Commons Attribution BY 4.0 license
Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Mossakowski Medical Research Institute PAS
Library of the Mossakowski Medical Research Institute PAS
Mar 24, 2022
Feb 15, 2019
100
https://rcin.org.pl./publication/89730
Mossakowski, Mirosław Jan (1929–2001)
Mossakowski, Mirosław Jan (1929–2001) Kwiatkowska-Patzer, Barbara
Gadamski, Roman (1933–2015) Mossakowski, Mirosław Jan (1929–2001)
Gajkowska, Barbara Mossakowski, Mirosław Jan (1929–2001)
Gajkowska, Barbara Mossakowski, Mirosław Jan (1929–2001)
Mossakowski, Mirosław Jan (1929–2001)
Mossakowski, Mirosław Jan (1929–2001) Gadamski, Roman (1933–2015)
Mossakowski, Mirosław Jan (1929–2001) Gajkowska, Barbara