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File of histopathological evaluation of nervous system diseases (1965) - nr 22/65
Institutional creator:Department of Experimental and Clinical Neuropathology MMRI
Contributor: Place of publishing: Date issued/created: Description:Clinical, anatomical and histological diagnosis
Subject and Keywords:Vascular disaeses - atherosclerosis ; Cerebellum - purkinje cell loss ; Cerebral cortex necrosis ; Midbrain - cell disintegration substantia nigra
Abstract:Histological diagnosis: Arterio et arteriosclerosis gradus mediocris. Atrophia simplex. Status lacunaris. Autopsy examination of 78-year-old patient was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, Heidenhain and Van Gieson's method.In analyzed specimens, significant thinning of neural cellular elements was observed in both cortex and brain stem, as well as strongly expressed features of ischemia in a significant proportion of cells. Generalized gliosis was visible. In the cerebral cortex, regional necrosis was seen. In the white matter of the cerebral hemispheres, sinuses of various sizes surrounded by starchy bodies were locally found; in the midbrain, partial disintegration of substancia nigra cells was seen; within the cerebellum, partial loss of Purkinje cells was observed. Medium-caliber vessels had thin smooth muscle layer and thick adventitia. Staining for myelin was less intense in areas of thinned tissue.
Resource type: Format: Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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