Title:

Studies of heart ultrastructure in various diseass by prof A. Fidziańska-Dolot: laminopathy - 55/10

Creator:

Fidziańska-Dolot, Anna (1930–2015)

Institutional creator:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular Diseases

Contributor:

Walczak, Ewa

Place of publishing:

Warsaw

Date issued/created:

2010

Description:

Electron microscopy analysis of the heart biopsy

Subject and Keywords:

Laminopathy

Abstract:

Ultrastructural analysis revealed myofibrilar disruption and disorganization,focally significant or complete loss of myofibrils,resulting in the formation of vacuolated spaces, also under the sarcolemma and in the vicinity of nuclei (Figs.1-12).Features characteristic for laminopathy were observed. The nuclei of cardiomyocytes were abnormally shaped,the nuclear envelope was corrugated,with numerous indentations (Figs. 13-17). Altered mitochondria,characterized by bright mitochondrial matrix,loss or abnormal arrangement of cristae were present.Autophagy was locally observed (Figs.18-20).

Resource type:

Text ; Image

Detailed Resource Type:

Files ; Photography

Format:

pdf

Language:

pol ; eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open