Metadata language
Mystery of orphan Open Reading Frames (ORFans) ; Biotechnologia
Subtitle:Mystery of orphan Open Reading Frames (ORFans) ; Journal of Biotechnology, Computational Biology and Bionanotechnology
Creator:Mackiewicz, Paweł ; Bączkowski, Krystian ; Sobczyński, Maciej ; Cebrat, Stanisław
Publisher:Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Date issued/created: Type of object: Subject and Keywords: Abstract:In spite of an increase of a number of sequenced genomes, 20-30% of Open Reading Frames (ORFs) do not show detectable sequence similarity to other sequences in databases and functions of their products have not been recognized. These ORFs are called ORFans and their abundance has been referred to as a “mystery”. A large fraction of ORFans are probably spurious non-coding ORFs generated by protein coding sequences or repeat sequences. Some ORFans are probably quickly evolving genes specific to narrow phylogenetic lineages. The most interesting group of ORFans are de novo generated genes with new functions and structures which may find some applications in biotechnology and medicine. It is also possible that some ORFans code for RNA regulatory molecules.
Relation:Biotechnologia, vol.70, 3 (2005)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Library of Institute of Bioorganic Chemistry PAS
Language: Language of abstract: Temporal coverage: Rights:Creative Commons Attribution BY-SA 4.0 license
Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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