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From DNA sequence to antibiotic
Subtitle:From DNA sequence to antibiotic
Creator:Pawlik, Krzysztof ; Kotowska, Magdalena
Publisher:Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Date issued/created: Type of object: Subject and Keywords: Abstract:Progress in molecular biology, large number of known bacterial sequences and a number of microbiological genome sequencing projects finished or running allow to think about creating in vitro the DNA code in order to obtain new metabolites. Here, we describe the attempts of biosynthesis of new polyketides by designing new genes coding polyketide synthases. In assembling new polyketide synthases, the fragments of known genes are widely used. High homology of the polyketide synthase genes and a number of known produced polyketides give a possibility to describe a polyketide synthase on a DNA sequence level. Basing on known amino acid motifs, it is possible to determine enzymatic activities acting in the process of polyketide synthesis, and so to predict putative structure of the final metabolite. Successful artificial synthesis of 6-deoxyerythronolide B synthase genes show how near is the realization of the idea of producing new chemical compounds by creating DNA information.
Relation:Biotechnologia, vol.70, 3 (2005)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Library of Institute of Bioorganic Chemistry PAS
Language: Language of abstract: Temporal coverage: Rights:Creative Commons Attribution BY-SA 4.0 license
Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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