Title:

Studies of heart ultrastructure in various diseases by prof A. Fidziańska-Dolot: dilated cardiomyopathy - 752 (41/04)

Creator:

Fidziańska-Dolot, Anna (1930–2015)

Institutional creator:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular Diseases

Contributor:

Walczak, Ewa

Place of publishing:

Warsaw

Date issued/created:

2004

Description:

Electron microscopy analysis of the heart biopsy

Subject and Keywords:

Dilated cardiomyopathy

Abstract:

Dilated cardiomyopathy. Ultrastructural analysis revealed a number of abnormalities in the cardiomyocytes structure.Changed sarcomere pattern, disorganization of myofibrils and in many areas their complete atrophy were observed. Mitochondria partially devoid of mitochondrial cristae were seen in the sarcoplasm and connective tissue was abundant in the extracellular space. Cardiomyocyte nuclei were abnormally shaped, nuclear envelope was corrugated ,with numerous indentations, and in some nucler broken.Mitochondria were characterized by bright matrix and partial loss of cristae . Mitochondria with a dark mitochondrial matrix, containing characteristic inclusions or glycogen in their interior, as well as giant mitochondria, many times larger than normal, were also observed .

Resource type:

Text ; Image

Detailed Resource Type:

Files ; Photography

Format:

pdf

Language:

pol ; eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open