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Projektowanie nowych inhibitorów trombiny
Subtitle:Design of new thrombin inhibitors
Creator: Publisher:Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Date issued/created: Subject and Keywords: Abstract:Thrombin inhibitors are anticoagulants that inhibit clot formation. The most potent, knownthrombin inhibitor is hirudin, a 65 amino acid protein isolated from the salivary glands of themedicinal leech. An X-ray three — dimensional structure of the complex of hirudin with humana-thrombin has been recently reported. This review article describes the design based on thecrystal structure, of new synthetic hirudin analogs with reduced sequence and enhanced proteolytic stability.
Relation:Biotechnologia, vol.25, 2 (1994)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Biblioteka Instytutu Chemii Bioorganicznej PAN
Language: Language of abstract: Temporal coverage: Rights:Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Terms of use: Digitizing institution:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Original in:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
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