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Gene therapy of cardiovascular diseases
Subtitle:Gene therapy of cardiovascular diseases
Creator: Publisher:Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Date issued/created: Subject and Keywords: Abstract:Gene therapy is suggested to be beneficial for the treatment of diseases whichare difficult or impossible to be cured by classical pharmacotherapy. Thus, the transfer of genetic material of potential therapeutic properties may be particularly helpfulin the treatment of hereditary genetic disorders and cancer. However, serious technical obstacles, especially the lack of efficient vectors for the delivery oftherapeutic genes have so far prevented the achievement of convincing therapeutic effects. On theother hand, the complications of atherosclerosis, such as heart or peripheral ischaemia, seem to be good candidates for genetic strategies aimed particularly at stimulation of angiogenesis. As in this case therapeutic genes should be expressed locallyand in a short time there is a good chance that the application ofthis therapy will takeplace earlier than in the case of other disorders. In this paper the first gene therapyclinical trials in human cardiovascular diseases are described. The latest investigationson the basic mechanisms of the blood vessel wall physiology and relationships between factors involved in angiogenesis are also briefly mentioned
Relation:Biotechnologia, vol.48, 1 (2000)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Library of Institute of Bioorganic Chemistry PAS
Language: Language of abstract: Temporal coverage: Rights:Creative Commons Attribution BY-SA 4.0 license
Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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