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Nonaqueous media - site of enzymatic catalysis
Subtitle:Nonaqueous media - site of enzymatic catalysis
Creator:Bancerz, Renata ; Ginalska, Grażyna
Publisher:Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Date issued/created: Subject and Keywords: Abstract:Lipases, esterases, acylases, glycosidases, aldolases are the most used enzymes in synthetic organic chemistry. Among the biocatalysts, lipases are the most frequently used. This class of enzymes is able to catalyze the hydrolysis of carboxylic acid esters in aqueous medium on the reverse reaction in organic solvents. The use of enzymes in organic solvents is now well established and there are several advantages of conducting enzymatic reaction in water poor media such as increased solubility of hydrophobic substrates, shifting of thermodynamic equilibrium in favour of synthesis over hydrolysis and increased thermostability of the enzyme. However, the practical application of enzyme in organic solvents has been hampered by tbe low catalytic activities compared to those expressed in water. This review highlights recent research on the stabilization of enzymes using both chemical and biological means to increase the lifetime of the biocatalyst.
Relation:Biotechnologia, vol.87, 4 (2009)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Library of Institute of Bioorganic Chemistry PAS
Language: Language of abstract: Temporal coverage: Rights:Creative Commons Attribution BY-SA 4.0 license
Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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