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Mossakowski, Mirosław Jan (1929–2001) ; Wrzołkowa, Teresa ; Tukaj, Cecylia ; Gadamski, Roman (1933–2015)
Publisher: Place of publishing: Date issued/created: Type of object: Subject and Keywords:terminal vascularization ; Hippocampus ; selective vulnerability ; morphometry
Abstract:Comparative morphometric analysis of terminal vascularization (vessels with a diameter lower than 12.5 /ли) in theischemia-sensitive sector CAI and the ischemia-resistant sector CA3 of Ammon's horn in Mongolian gerbils was performed. Basing on numerous computer-counted parameters characterizing the terminal vascular network in bothhippocampal sectors and its relationship to the surrounding tissue, it was shown that a number of capillary vessels, theiraverage diameter, and exchange and flow surfaces were to a statistically significant degree lower in the pyramidal layer ofthe CAI sector as compared with those in CA3 sector. The number of pyramidal neurons in the pyramidal layer, counted per surface unit was in sector CAI higher than in sector CA3. The obtained data indicate clearly anangioarchitectonically dependent lower microvascular capacity of sector CA 1. However, these differences do not indicateper ле a leading role of the vascular factor in the pathomechanism of selective vulnerability to ischemia. They may be a factor facilitating neuronal damage evoked by the excitotoxic action of glutamate, observed in CAI sector as a result of forebrain ischemia.
Relation: Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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