Postresuscitation changes of blood-brain barrier permeability and their possible pathogenetic importance.

Gannushkina I.V.; Mossakowski, Mirosław Jan (1929 - 2001) i in.

- ris
- BibTeX
- EndNote
- Csv

Postresuscitation changes of blood-brain barrier permeability and their possible pathogenetic importance. Postreanimacjonnye izmenenija pronicaemosti gematoencefalicheskogo bar'iera i ich vozmoźnoe patogeneticheskoe znachenie Gannushkina I.V.Mossakowski, Mirosław Jan (1929 - 2001) i in.

Postresuscitation changes of blood-brain barrier permeability and their possible pathogenetic importance. ; Postreanimacjonnye izmenenija pronicaemosti gematoencefalicheskogo bar'iera i ich vozmoźnoe patogeneticheskoe znachenie

Gannushkina I.V. ; Mossakowski, Mirosław Jan (1929 - 2001) i in.

Blood, proteins -- metabolism ; Immunoglobulins-- metabolism ; Brain diseases-- physiopathology ; Blood-brain barrier -- physiology

Experiments were conducted on, rats, with temporary (10 min) clamoing of the thoracic vascular bundle and subsequent resuscitation to study the premeability of the blood-brain barrier (BBB) to plasma albumins and globulins and to blood plasma immunoglobulins in different stages of the postresuscitation period> Mild increase of BBB premeability was detected 3 minutes after the beginning of recirculation. Promeability increased markedly in 24 hours and continued growing by the 72nd hour. At s 1-3 hour interval in recirculation the BBB was closed. The obtained results discodse the mechanisms of the development of autoimmune cerebral disorders in on organism that experienced cardiac arrest and resuscitation.

Patołogicheskaja Fizjologija i Eksperimentalnaja Terapija