Title:

AKTYWNOŚĆ NUKLEOZYDO-DWU- I TRÓJ-FOSFATAZ W MÓZGU SZCZURA W OSTRYM ZATRUCIU TLENKIEM WĘGLA

Subtitle:

Activity of nucleoside di- and triphosphatase in rat brain in acute carbon monoxide poisoning. Light and electron microscopy studies

Creator:

Szumańska, Grażyna ; Ostenda, Maria ; Mossakowski, Mirosław Jan (1929–2001)

Contributor:

Stowarzyszenie Neuropatologów Polskich

Publisher:

Państwowy Zakład Wydawnictw Lekarskich

Place of publishing:

Warszawa

Date issued/created:

1976

Subject and Keywords:

carbon monoxide intoxication ; phosphatases

Abstract:

The studies concerned the activity of nucleoside phosphatases in cellular elementsof the blood-brain interphase in rats subjected to carbon monoxide intoxication.On the light microscopy significant reduction of enzymatic activity in the bloodvessel walls and in cellular elements of the nerve tissue was observed at 20thmin of CO poisoning. This was followed by its increase observed in the periodbetween the end of intoxication and 4th hour of recovery. Normalization of thehistochemical picture was noted 24 and 48 hours following CO poisoning.On electron microscopy level at 20th min of intoxication deposits indicating thesite of enzyme activity were localized in the basal membranes of capillaries aswell as an the cell membranes of perivascular glia, being accumulated in intermembraneousspaces. First hours of the postintoxication period were characterizedby significant reduction of the electron dense deposits in the capillary basalmembranes, their unequal distribution, progressive diminution of their accumulationon the cell membranes of perivascular glia and by their abnormal distributionin neurons and glial cells. At 24th hr following intoxication electron microscopic picture of the enzymatic activity in experimental animals did not show any differences as compared to the control ones. The above presented enzymatic changes in cellular elements of the blood-brain interphase have been considered as abnormalities accompanying the evolution of cytotoxic brain edema occurring in those experimental conditions.

Relation:

Neuropatologia Polska

Volume:

14

Issue:

2

Start page:

197

End page:

207

Resource type:

Text

Detailed Resource Type:

Article

Format:

pdf

Language:

pol

Language of abstract:

eng ; rus

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open