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Mossakowski, Mirosław Jan (1929–2001) ; Gadamski, Roman (1933–2015)
Publisher:Zakład im. Ossolińskich - Wydawnictwo Polskiej Akademii Nauk
Place of publishing: Date issued/created: Type of object: Subject and Keywords:Wapń ; Niedokrwienie mózgu ; neurony ; róg Ammona
Abstract:The protective effect of Nimotop (Bayer) — a calcium channel blocker, beingan equivalent of nimodipine, on the development of selective damage of CAi neuronsof Ammon’s horn resulting from short-term ischemia of forebrain in Mongoliangerbils was evaluated. The experimental animals, subjected to 7.5 min bilateralligation of common carotid arteries were given the drug in a dosis of 1 mg/kgbody weight in the form of intraperitoneal injection at various periods in relationto cerebral ischemia. In group 1 — Nimotop was administered twice — 60 mjnbefore ischemia and 5 h after arterial release. In group 2 a double dosis of thedrug was given 15 min prior to carotid occlusion and in 3rd hour of the recirculation.In group 3 the scheme applied in group 2 was supplemented with a thirddosis of Nimotop given 24 h following cerebral ischemia. The latter was the timeof a single drug dosis application in group 4. The control animals were subjectedto cerebral ischemia with no medication.
Relation: Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Language: Language of abstract: Rights:Licencja Creative Commons Uznanie autorstwa 4.0
Terms of use:Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -
Digitizing institution:Instytut Ochrony Przyrody Polskiej Akademii Nauk
Original in:Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
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