Title:

Cytochrome P-450 metabolites in renal circulation and excretion with the nitric oxide (NO) system

Creator:

Kompanowska-Jezierska, Elżbieta ; Kuczeriszka, Marta

Contributor:

Laboratory of Renal and Body Fluid Physiology, M. Mossakowski Medical Research Centre,Polish Academy of Sciences, Warsaw, Poland

Publisher:

Polish Physiological Society

Place of publishing:

Krakow

Date issued/created:

2008

Type of object:

Czasopismo/Artykuł

Subject and Keywords:

CYP-450 metabolites ; NOS ; Sodium intake ; Intrarenal circulation ; Renal excretion

Abstract:

The role of CYP-450 dependent arachidonic acid (AA) metabolites (vasoconstrictor 20-HETE and vasodilator EETs) and NO in control of blood pressure (MABP) and kidney function remains unclear. NO affects the activity of heme-containing enzymes, like CYP-450 related monooxygenases, moreover, their activity depends on Na(+) intake. The focus of this review and underlying studies is on the role of high sodium intake (pro-hypertensive factor) in interrelation between CYP-450 and NOS. The acute vs. chronic non-selective inhibition of CYP-450 AA metabolites (ABT), and selective inhibition of 20-HETE (HET 0016) has also been tested. The renal artery flow (RBF, Transonic probe), medullary blood flow (MBF, laser-Doppler flux), renal excretion, and medullary tissue NO (selective electrode) were measured in male anaesthetized Wistar rats. We conclude that on standard Na(+) intake, opposed effects of 20-HETE and EETs are almost in equilibrium; however, in the renal circulation the vasodilator EETs influence slightly prevails. High sodium intake stimulates NOS, which limits CYP-450 impact on MABP and kidney function. However, this protection disappears after prolonged sodium intake. Long-lasting high sodium intake lowers NO bioavailability and promotes systemic and intrarenal vasoconstrictor activity of 20-HETE. Opposed effects of NO and AA metabolites of CYP-450 on water and solute excretion are also described.

Relation:

Journal of Physiology and Pharmacology

Volume:

59

Issue:

Suppl 9

Start page:

137

End page:

149

Resource type:

Tekst

Detailed Resource Type:

Artykuł przeglądowy

Format:

text/xml

Language:

eng

Language of abstract:

eng

Rights:

Prawa zastrzeżone - dostęp nieograniczony

Terms of use:

Zasób chroniony prawem autorskim. [CC BY 3.0 PL] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 3.0 Polska, której pełne postanowienia dostępne są pod adresem:

Digitizing institution:

Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk

Original in:

Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN

Projects co-financed by:

Program Operacyjny Innowacyjna Gospodarka, lata 2010-2014, Priorytet 2. Infrastruktura strefy B + R

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