Title:

File of histopathological evaluation of nervous system diseases (1965) - nr 121/65

Institutional creator:

Department of Experimental and Clinical Neuropathology MMRI

Contributor:

I. Zelman, doc.

Place of publishing:

Warsaw

Date issued/created:

1965

Description:

Clinical, anatomical and histological diagnosis

Subject and Keywords:

Phenylketonuria ; Metabolic diseases

Abstract:

Histological diagnosis: Phenylketonuria. Autopsy examination of 1-year-old child was performed. Neuropathological evaluation in light microscopy was based on brain paraffin sections stained with Hematoxylin-eosin, Cresyl-violet and Heidenhain method.Morphological examination revealed that the brain was small in relation to the child's weight, gyrus were small, and the ventricular system was dilated. Microscopically, a generalized reduction of white matter in relation to the grey structures was very evident, and within it there was marked demyelination, more severe in the cerebral hemispheres, less in the cerebellum. It was accompanied by tissue damage with foci of spongiform necrosis and cell-fibrous gliosis. Grey structures and especially the cerebral cortex also showed significant damage.Histological diagnosis: Phenylketonuria

Resource type:

Text

Format:

pdf

Language:

pol

Language of abstract:

eng

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open