Metadata language
Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology
Subtitle:Perspectives for Medicinal Applications of Synthetic Oligonucleotides: Antisense Technology
Creator:Stec, Wojciech J. ; Guga, Piotr
Publisher:Komitet Biotechnologii PAN ; Instytut Chemii Bioorganicznej PAN
Date issued/created: Description:Zeszyt specjalny. Polish - Japan Issue
Subject and Keywords: Abstract:Pharmaceutical industry is entering the era of “chirotechnology revolution”: in many countriesjany potential drug containing asymmetry centres has to be tested in its stereochemically pureforms. In the authors’ laboratory many efforts have been made, with a certain extent of success,to stereocontrolled chemical synthesis of oligonucleoside phosphorothioates and methanephosphonates. Stability of stereoregular oligonucleotides towards selected nucleases, as well as thethermal stability of duplexes formed with DNA and RNA were investigated. Other strategiesleading to antisense oligonucleotides try to avoid P-chirality by replacement of phosphates withachiral phosphorodithioates or moieties like formacetal, sulphones, diethylsilo.xanes etc.
Relation:Biotechnologia, vol.35, 4 (1996)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Biblioteka Instytutu Chemii Bioorganicznej PAN
Language: Language of abstract: Temporal coverage: Rights:Licencja Creative Commons Uznanie autorstwa-Na tych samych warunkach 4.0
Terms of use: Digitizing institution:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Original in:Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Projects co-financed by: Access: