Title:

Files for neuromuscular diseases (2012) - nr 70/12

Creator:

Fidziańska-Dolot, Anna (1930–2015)

Contributor:

Mossakowski Medical Research Center Polish Academy of Sciences. Department of Neuromuscular

Place of publishing:

Warsaw

Date issued/created:

2012

Description:

Muscle segment examination in electron microscopy

Subject and Keywords:

Myopathy

Abstract:

Po A 4-year-old patient was examined. A biopsy of quadriceps sinister was performed. Electronmicroscopy analysis revealed ultrastructurally changed myofibres. The vast majority of muscle fibers were characterized by centrally located nuclei, usually single or in number of two (Fig. 1,2,3,4,5,6.) In some fibers in the longitudinal section we observed a centrally arranged row of many nuclei and the evident loss of myofibril was seen (Fig. 7). The disruption of the contractile apparatus was observed, especially near the cell nuclei (Fig. 8,9,10). Abundant connective tissue was visible (Fig. 11). Ultrastructural and clinical picture suggests centronuclear myopathy associated with inappropriate BIN1 gene activity.

Resource type:

Text

Detailed Resource Type:

Photography ; Files

Format:

pdf

Language:

pol

Rights:

Creative Commons Attribution BY 4.0 license

Terms of use:

Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -

Digitizing institution:

Mossakowski Medical Research Institute PAS

Original in:

Library of the Mossakowski Medical Research Institute PAS

Projects co-financed by:

Operational Program Digital Poland, 2014-2020, Measure 2.3: Digital accessibility and usefulness of public sector information; funds from the European Regional Development Fund and national co-financing from the state budget.

Access:

Open