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The influence of sorbitol on photooxidation-mediated crosslinking of porcine pericardial collagen
Subtitle:The influence of sorbitol on photooxidation-mediated crosslinking of porcine pericardial collagen
Creator:Wisowski, Grzegorz ; Olczyk, Krystyna ; Koźma, Ewa M. ; Jura-Półtorak, Agnieszka ; Olczyk, Paweł ; Kuźnik-Trocha, Kornelia
Publisher:Committee on Biotechnology PAS ; Institute of Bioorganic Chemistry PAS
Date issued/created: Subject and Keywords: Abstract:Collagen is one of the most useful biomaterials. The medical application of collagen tissues requires specific fixation procedures. Dye-mediated photooxidation is a method of the new collagen crosslink formation. In this study, the influence of sorbitol on the extent of porcine pericardial collagen crosslinking was investigated. The collagen modification was estimated on the basis of pericardial susceptibility to pepsin digestion. The hydrolysate components were characterized electrophoretically. The significant collagen crosslinking was found in all photooxidized samples, in comparison with the untreated ones. However, the most enhanced collagen modification was observed for pericardium photo- oxidized with 0,5% and 0,9% sorbitol, as compared to the samples fixed without sorbitol.
Relation:Biotechnologia, vol.71, 4 (2005)-.
Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Resource Identifier: Source:Library of Institute of Bioorganic Chemistry PAS
Language: Language of abstract: Temporal coverage: Rights:Creative Commons Attribution BY-SA 4.0 license
Terms of use: Digitizing institution:Institute of Bioorganic Chemistry of the Polish Academy of Science
Original in:Institute of Bioorganic Chemistry of the Polish Academy of Science
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