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Sokołowski, Jerzy ; Olszewski, Waldemar
Publisher: Place of publishing: Date issued/created: Type of object: Abstract:Healthy dogs divided into two groups were administered immunosuppressive agent Immuran in scope to assess organ lesions resulting from this drug. Dogs of the 1st group received low doses of Immuran, usually applied after organ transplan¬tation. In this group Immuran was administred for a 6-month period. Dogs belonging to the 2nd group were administered toxic doses of Immuran, like those used in the period of acute transplant rejection. Following symptoms and lesions were noted in both these groups: loss of body weight, leukopenia, hypalbuminemia, va¬nishing of lymphatic tissue and lesions in parenchymatous organs. One half of dogs of the 1st group survived the experimentation meanwhile all dogs of the second group died. Histological examination reveled that alterations in kidneys and livers due to Immuran administration differed from those found in allotransplants of these organs.
Relation: Volume: Issue: Start page: End page: Resource type: Detailed Resource Type: Format: Language: Language of abstract: Rights:Creative Commons Attribution BY 4.0 license
Terms of use:Copyright-protected material. [CC BY 4.0] May be used within the scope specified in Creative Commons Attribution BY 4.0 license, full text available at: ; -
Copyright holder: Digitizing institution:Mossakowski Medical Research Institute PAS
Original in:Library of the Mossakowski Medical Research Institute PAS
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