Michalski, Andrzej ; Łukasiewicz, Hanna ; Olszewski, Waldemar ; Nielubowicz, Jan
Experimental investigations, consisting in intravenous administration of various amounts of the pancreatic juice were carried out in dogs. Pancreatic juice was taken sterilely from the dog-donor. Experiments were done in 5 groups. In the 1st group gradually increasing amounts of the pancreatic juice were administered to 7 dogs, with purpose to determine eventual lethal dose. In the 2nd group, 11 dogs received pancreatic juice in amount more than 55 ml/kg of body weight. In the 3rd group, 3 dogs were administered inactivated pancreatic juice, also in amount more than 55 ml/kg of body weight. In the 4th group 3 dogs were administered intravenously 0,9% of natrium chloride solution with merthiolate added. In the 5th group 3 dogs received transfusion of 100 mg of trypsine, dissolved in borate buffer solution (acc. to Michaelis). Foilwing results were obtained: pancreatic juice administered intravenously in amount of 55 ml/kg of body weight, during some 20—25 minutes, caused death of the experimental animals. All remaining animals survived.Clinical symptoms observed after pancreatic juice administration seem to be causally joined with the action of the group of pancreatic enzymes. Attemps to determine which a these enzymes arc responsible for tht described effect, failed
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Zasób chroniony prawem autorskim. [CC BY 4.0 Międzynarodowe] Korzystanie dozwolone zgodnie z licencją Creative Commons Uznanie autorstwa 4.0, której pełne postanowienia dostępne są pod adresem: ; -
Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego Polskiej Akademii Nauk
Biblioteka Instytutu Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Mar 25, 2022
Sep 23, 2019
239
https://rcin.org.pl./publication/105528
Edition name | Date |
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Rowiński, Wojciech, 1965, Badania patogenezy ostrej martwicy trzustki | Mar 25, 2022 |
Olszewski, Waldemar Łukasiewicz, Hanna Rowiński, Wojciech
Rowiński, Wojciech Łukasiewicz, Hanna Olszewski, Waldemar
Michalski, Andrzej Olszewski, Waldemar Rowiński, Wojciech
Rosnowska, Maria Olszewski, Waldemar Rowiński, Wojciech i in.
Sobociński, Wojciech Kajzer, Krzysztof Rowiński, Patryk Zub, Karol
Sobociński, Wojciech Kajzer, Krzysztof Rowiński, Patryk Zub, Karol
Olszewski, Waldemar Rowiński, Wojciech Olszewska, Krystyna i in.