@misc{_Wpływ,
 copyright={Rights Reserved - Restricted Access},
 address={Warszwa},
 howpublished={online},
 language={pol},
 abstract={Multiple sclerosis (MS) is an autoimmune disease , which leads to neurodegeneration , affecting increasing number of people in the developed countries of the temperate climate.As the etiology of the disease remains still unkown, the available MS therapies are mainly symptomatic. Therapies the target specific processes involved in the pathomechanism of MS often does not show the desired effect, or carry the risk of serious side effects. It is therefore a continuous search for new treatments for multiple sclerosis. Experiments described in this paper make use of the naturally occurring phenomenon of oral tolerance , where the reduction of the immune response to previously orally administered antigen is observed. As a source of myelin antigenes we used the pig spinal cord hydrolyzate, as well as recombinant lactic acid bacteria Lactococcus lactis producing theree selectd immunogenic fragments of myelin proteins. The results indicate that the use of such preparations , administered orally to rats with induced experimental allergic encephalomyelitis (animal model of MS) attenuated the clinical signs observed in animals , and also reduced the analyzed neuroimmunological symptoms.},
 type={Text},
 title={Wpływ antygenów mieliny podawanych drogą pokarmową na zmiany neurologiczne i neuroimmunologiczne w modelu zwierzęcym stwardnienia rozsianego},
}