@misc{Małuszyńska_Jolanta_Nucleic_1995, author={Małuszyńska, Jolanta}, volume={29}, number={2}, copyright={Creative Commons Attribution BY-SA 4.0 license}, journal={Biotechnologia, vol.29, 2 (1995)-.}, howpublished={online}, year={1995}, publisher={Committee on Biotechnology PAS}, publisher={Institute of Bioorganic Chemistry PAS}, language={pol}, abstract={In situ hybridization (ISH) provides a highly sensitive method for the detection of specificnucleic acid sequences in cells, nuclei and metaphase chromosomes. This technique has beenimproved continuously since it was first established in 1969. Especially fluorescent in situ hybridization (FISH) rapidly replaced radioactive procedures and became a conventional tool incytogenetic research. ISH plays an increasingly important role in a variety of research areas ofmedicine, genetics and plant breeding. It has been successfully applied for chromosome orchromosome fragments identification, chromosomal abnormalities detection, gene mapping orspecific DNA sequences localization.}, title={Nucleic acid in sifu hybridization; from ISH to DIRVISH}, type={Text}, URL={http://rcin.org.pl./Content/147872/PDF/POZN271_183456_biotechnologia-1995-no2-maluszynska.pdf}, keywords={biotechnology}, }